pseudotyped lentiviruses efficiently target ephrinB 2 + stem cell
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چکیده
word count: 249 words 21 Text word count (excluding references, table footnotes and figure legends): 7,277 words 22 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.02032-12 JVI Accepts, published online ahead of print on 28 November 2012 on O cber 6, 2017 by gest http/jvi.asm .rg/ D ow nladed fom on O cber 6, 2017 by gest http/jvi.asm .rg/ D ow nladed fom on O cber 6, 2017 by gest http/jvi.asm .rg/ D ow nladed fom
منابع مشابه
Title : Nipah virus envelope pseudotyped lentiviruses efficiently target ephrinB 2 + stem cell
word count: 249 words 21 Text word count (excluding references, table footnotes and figure legends): 7,277 words 22 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.02032-12 JVI Accepts, published online ahead of print on 28 November 2012 on O cber 8, 2017 by gest http/jvi.asm .rg/ D ow nladed fom on O cber 8, 2017 by gest http/jvi.asm .rg/ D o...
متن کاملNipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo.
Sophisticated retargeting systems for lentiviral vectors have been developed in recent years. Most seek to suppress the viral envelope's natural tropism while modifying the receptor-binding domain such that its tropism is determined by the specificity of the engineered ligand-binding motif. Here we took advantage of the natural tropism of Nipah virus (NiV), whose attachment envelope glycoprotei...
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The ability to visualize and genetically manipulate specific cell populations of the central nervous system (CNS) is fundamental to a better understanding of brain functions at the cellular and molecular levels. Tools to selectively target cells of the CNS include molecular genetics, imaging, and use of transgenic animals. However, these approaches are technically challenging, time consuming, a...
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Lentivirus vectors can transduce dividing and nondividing cells. Using three-plasmid transient transfections, high-titer (>10(9) IU/ml) recombinant lentivirus vectors pseudotyped with vesicular stomatitis virus G (VSV-G) protein can be generated (T. Kafri et al., Nat. Genet. 17:314-317, 1997; H. Miyoshi et al., Proc. Natl. Acad. Sci. USA 94:10319-10323, 1997; L. Naldini et al., Science 272:263-...
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Pseudotyped vectors can be used to introduce genes into cells or to study the entry process of the virus from which the outer shell of the recombinant virus is derived. Recently, several novel pseudotyped retroviruses and lentiviruses have been constructed. Virus vectors pseudotyped with an alphavirus glycoprotein hold special promise. The increasing diversity of the available pseudotyped vecto...
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